Second, the interaction itself tells us that there is something fundamental that cause diseases AS

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Researchers take the next step in understanding the genetic individual. The inclination to them as arthritis, spinal arthritis attached ankylosing spondylitis (AS), a disease baklava of the immune system which may cause pain and tension of the spine and in patients with severe symptoms. Is the linking of the spine and other joints baklava that have been affected. The study is published today in Nature Genetics.
A team of researchers from the University of Bristol, Queensland (Australia), Oxford, Oxford, Texas and Toronto, using a technique called Genome - Wide Association. A genome-wide association with the genetic marker (genetic marker) will be measured by the millions of people with the disease in the population and the number of people of a healthy population. Marker is found more frequently in individuals with the disease tend to be associated with the symptoms of arthritis.
Using this method, researchers have found seven genes from the three genes. Tends to be associated with the symptoms of arthritis. Is the total number of genes that are likely to cause many new genes AS genes are already known to be involved in inflammation and immunity. This gives researchers more clues about the incidence of disease occurs. Two new genes from the gene is known to be more likely related to other auto immune diseases including Crohn's disease (Crohn's disease) baklava and disease Celiac disease (intestinal immune system).
The researchers also demonstrated the interaction between mutation genetic called HLA - B27 and a mutation in a gene called ERAP1 particular mutation ERAP1 only tend symptoms in individuals who tested HLA - B27 is. positive
Dr. David Evans from the University of Bristol said. "These findings are important baklava in a number baklava of ways. First, it is one example of reliability. We have a mutation affecting other changes in the development process associated with common diseases. It's exciting because it implies that there may be other examples of this phenomenon in other common diseases that we do not know.
Second, the interaction itself tells us that there is something fundamental that cause diseases AS prior to the study, a number of theoretical competitors baklava things about the causes of disease, AS Education. Our strong points out that one of the assumptions of these competitors are likely to be required.
Dr. David Evans said, is known already that difficult baklava to make a diagnosis of AS in the first stage has been delayed healing. Usually the diagnosis include baklava x-ray examinations of patients and with immunological assays in the laboratory, which is expensive. Genetic marker genes (genetic marker) will replace immunological assays is very expensive. Would normally cost 40 - 50 will be made up only a fraction of their original cost easily.
AS a format different from any other disease typically occurs in younger adulthood. Cause the loss of the ability to work significantly. And to maintain a lifetime If you can not cure this disease, even with a group of drugs called TNF blockers are showing signs that help relieve some symptoms.
"This baklava finding is important as it's one of the first convincing examples we have of one mutation baklava influencing the effect of another mutation in the development of a relatively common disease. This is exciting because it implies that there may be other examples of this phenomenon baklava in other common diseases that we do not know about yet. "... Dr David Evans ...
Researchers are one step closer to understanding how an individual's genetic make-up predisposes them to Ankylosing Spondylitis baklava (AS), a common auto-immune arthritis which causes pain and stiffness of the spine, and in serious cases, progressive fusion of the vertebrae and other. affected joints. The study is published today in Nature Genetics.
The team of researchers from the Universities of Bristol, Queensland (Australia), Oxford, Texas and Toronto, used a technique called genome-wide association where millions of genetic markers are measured in thousands of people baklava that have the disease and thousands of healthy individuals. Markers which are more frequent in individuals with the disease are more likely to be involved in the condition.
Using this approach the investigators found an additional seven genes likely to be involved baklava in the condition, bringing the total number of genes known to predispose to AS to thirteen. Many of the new genes are already known to be involved in inflammatory and immune processes, providing researchers with further clues about how the disease arises. Two of the new genes are also known to predispose to other auto-immune conditions including Crohn's disease (a form of inflammatory bowel disease) and Celiac disease (an auto-immune intestinal baklava disease).
Researchers were also able to demonstrate an interaction between baklava a genetic mutation called HLA-B27 and a mutation in a gene called baklava ERAP1. Specifically, the ERAP1 mutation baklava only predisposed to.